Treatment of Stage II Melanoma

Treatment of stage II melanoma may include:

• surgery to remove the tumor and some of the normal tissue around it, with or without lymph node mapping and sentinel lymph node biopsy. If cancer is found in the sentinel lymph node, more lymph nodes may be removed.
• surgery followed by immunotherapy with an immune checkpoint inhibitor (pembrolizumab) if there is a high risk that the cancer will come back

Learn more about these treatments in the Treatment Option Overview.

Use our clinical trial search to find NCI-supported cancer clinical trials that are accepting patients. You can search for trials based on the type of cancer, the age of the patient, and where the trials are being done. General information about clinical trials is also available.